Heartburn meds are messing with your microbiome
In a paper published this week in the journal Gut Imhann et al., identify changes towards a less healthy gut microbiome in patients using Proton pump inhibitors (PPI).
Proton pump inhibitors (PPIs) are used to treat Gastro-esophageal Reflux Disease (GORD) and to prevent gastric and duodenal ulcers. 25% of the general population report having heartburn at least once a month, explaining the large demand for PPIs. In fact Proton pump inhibitors feature in the top 10 most widely used drugs in the world. Their use is associated with an increased risk of intestinal infections, most notably a 65% increase in the incidence of Clostridium difficile (often referred to as C. diff), infection.
In this study of 1815 adults, including healthy subjects and patients with Gastro-Intestinal diseases, the authors found that PPI use is associated with decreased bacterial diversity and profound changes in the gut microbiome. Oral bacteria and pathogenic bacteria were increased in the guts of PPi users and the observed changes were more noticeable than changes associated with antibiotics.
You can read the full article here.
Imhann F., et al., (2015) Proton pump inhibitors affect the gut microbiome. Gut. Dec. 9. doi:10.1136/gutjnl-2015-310376
Microbiome bites August 5th, 2018:
Short-Chain Fatty Acids Relieve Stress
Microbiome Bites July 22nd, 2018:
Autism Risk Determined by Mother’s Microbiome
Microbiome Bites July 18th, 2018:
Prebiotic Fiber Prevents Autoimmune Neurological Disease
Microbiome Bites July 8th, 2018
Skin Microbiome Protects Against Cancer
Microbiome Bites June 17th, 2018:
Scientist Finally Know How A Ketogenic Diet Protects Against Epilepsy
Microbiome Bites June 12th, 2018:
Probiotics Could Protect Against Stress
Microbiome Bites June 2nd, 2018:
Boosting The Gut Microbiome To Increase Longevity
Microbiome Bites May 13th, 2018:
Scientists Manipulate the Gut Microbiomes of Mice with Nori Seaweed
Microbiome Bite May 7th, 2018:
Health Benefits of Walnuts Linked to Gut Microbiome Effects
MIcrobiome Bites April 26th, 2018:
Kefir May Lower Blood Pressure by Boosting Gut-Brain Communication